Vicodin ES contains a combination of acetaminophen and hydrocodone. Hydrocodone is in a group of drugs called narcotic pain relievers. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone. You can purchase Vicodin without prescription at low price. Vicodin ES is used to relieve moderate to severe pain. Vicodin ES may also be used for purposes not listed in this medication guide.