Specification :

It is only produced in significant amounts during pregnancy as it is made by the placenta from 16-OHDHEAS, an androgen steroid made in the fetal liver and adrenal glands.

The Human placenta produces Pregnenolone and Progesterone from circulating Cholesterol. Pregnenolone is converted in the fetal adrenal gland into Dehydroepiandrosterone (DHEA), a C19 steroid, then subsequently sulfonated to DHEAS. DHEAS is converted via 16-OH DHEAS, in the fetal liver. In the placenta, 16-OH DHEAS is converted to estriol, and is the predominant site of estriol synthesis.

Levels of estriol in non-pregnant women do not change much after menopause, and levels are not significantly different from levels in men.

Product Name: Estriol
Synonyms: oestriol; 1,3,5(10)-Estratriene-3,16a,17b-triol; Estra-1,3,5(10)-triene-3,16alpha,17beta-triol
CAS RN.: 50-27-1
EINECS: 200-022-2
Molecular Weight: 288.38
Molecular Formula: C18H24O3
Melting Point(Celsius degree): 281-282