NVP-TAE684

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Biological Activity:
NVP-TAE684 is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 * * * * * -TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle * * * * * vivo, NVP-TAE684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas.

Technical Data:
M.Wt: 614.2
Formula: C30H40ClN7O3S
Solubility: Soluble in DMSO
Purity: > 99%
Storage: -20C 2 years
CAS 761439-42-3

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