Specification :
Sodium Hyaluronate
( Hyaluronic Acid, Sodium Salt)
INCI Name : Sodium Hyaluronate
Synonyms : Hyaluronic acid, sodium salt; Hyaluronan; Hyaluronate HA for short name
INN Name Hyaluronate Sodium [ USAN; JAN]
CAS No. : 9067-32-7 ( sodium hyaluronate) ; 9004-61-9 ( hyaluronic acid) ;
31799-91-4 ( potassium hyaluronate)
EINESC/ ELINCS No. : 232-678-0 ( hyaluronic acid)
Molecular Formula : ( C14H21NO11) n
Action
. Lubricating
. Tissue hydrodynamics
. Responsible for the resilience of cartilage
. Movement and proliferation of cells
. Tissue repair, such as sunburn
. Promote brain development
Application
Medical applications
1.1 Ophthalmic surgery
Corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment, intra-ocular lens implantation ( IOL implantation )
1.2 Wound repair
Postoperative tissue healing, such as after cataract surgery
Chronic wounds due to diabetes
Repair injured eyes
1.3 Lubricating
Exceptional lubricating properties necessary for skin, heart valves, aqueous/ vitreous humor of the eye and synovial fluid ( joint lubricant)
1.4 Osteoarthritis
Human or equine arthritis
Ankle and shoulder osteoarthritis pain
1.5 Prevent post-operative adhesions
1.6 Dry, scaly skin ( xerosis)
e.g. atopic dermatitis ( eczema)
Cosmetic applications
2.1 Moisturizing
1) Water holding capacity
Fig 1 shows that the water holding capacity of sodium hyaluronate is extremely high as compared to other moisturizers
2) Water retention
Fig 2 shows that the water evaporation rate of sodium hyaluronate is less than that of other moisturizers, which indicate that sodium hyaluronate possesses strong water retention properties.
3) Water uptake ( hygroscopic property)
At low humidity ( RH 33% ) , sodium hyaluronate has the highest moisture absorbing ability, while at high humidity ( RH 75% ) , it’ s water absorbing property is the lowest.
2.2 Lubricating and Film Formation.
Sodium hyaluronate can form a film when applied on the skin. Its low skin slip resistance maintains excellent skin lubricity. It can also form a film on the surface of hair to moisture and lubricate hair and eliminate static electricity of hair, which make hair soft and easy to comb.
The presence of hyaluronic acid in epithelial tissue has been shown to promote keratinocyte proliferation and increase the presence of retinoic acid, effecting skin hydration. Hyaluronic acid' s interaction with CD44 drives collagen synthesis and normal skin function. Present in the extracellular matrix of basal keratinocytes, hyaluronic acid is critical to the structural integrity of the dermal collagen matrix. These benefits make hyaluronic acid a very effective topical humectant, however results may only be sustained as part of an ongoing treatment program.
2.3 Skin repair and rejuvenation
1) .Accelerate the regeneration of injured skin by promoting keratinocyte proliferation, increasing the presence of retinoic acid, effecting skin hydration, driving collagen synthesis.
A good synergetic effect is observed when it is formulated with EGF and heparin
2) . Clear away oxygen free radical. Especially low molecular weight of sodium hyaluronate is extremely helpful for the healing of sunburn, erythema and trauma on the skin,
2.4 Nourishing skin
Low molecular weight sodium hyaluronate and hyaluronic acid oligosaccharide ( HA-Oligo) can reach the corium layer of the skin so as to improve the content of water, nourish skin and expand blood capillary, improve microcirculation and absorption of nutriment.
2.5 Smooth wrinkles
Subcutaneous injection of hyaluronate for filling soft tissue defects such as facial wrinkles. Hyaluronan injections temporarily smooth wrinkles by adding volume under the skin, with effects typically lasting for six months
Use Level
Typically used at 0.1 - 1% .
Product Forms Available
1. Sodium Hyaluronate Powder
2. 1% Sodium Hyaluronate
3. Hyaluronic Acid Oligosaccharide ( HA-Oligo, in the form of acid and sodium salt, respectively)
