Remove wrinkle: Fibroblast Growth Factor, Acidic, aFGF

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Origin:

China

Fibroblast Growth Factor Acidic,
Recombinant, Human

Description:
Recombinant human fibroblast growth factor – acidic ( FGF-1, aFGF ) is a single polypeptide chain containing 141 amino acids and having a molecular mass of 15.5kDa. The sequence of this recombinant protein is identical to natural aFGF, except it contains a methionine residue attached to the N-terminus.

INCI Name : rh-polypeptide-11

Synonyms : aFGF, FGF-1, retina-derived growth factor,
heparin-binding growth factor ( class I or alpha) ,
astroglial growth factor I

Trade Name : MC-aFGF

1. Anti-wrinkle and Anti-aging
aEGF modulates the skin rejuvenating by kstimulation of cell proliferation
aEGF rejuvenates both the epidermal cells and the underlying fibroblast cells, which produce collagen, elastin, and hyaluronic acid, maintain human skin elasticity, and decrease cutaneous senescence.
The proliferation of epidermal cells enhanced the skin cells regeneration.

2. Wound healing and tissue repair
Angiogenic in vivo, stimulate cell proliferation on human vein endothelial cell, induce the formation of new capillary blood vessels. It binds to heparin, which potentiates its biological activity and protects it from proteolysis.

3. Rejuvenates hair follicle to produce new hair
aFGF can activate FGF-7, promote hair growth by stimulation of cell proliferation on primary hair cell, treat or prevent baldness.

4. Mitogenic for a variety of mesenchymal and neuroectodermal cells
It promotes DNA synthesis, stimulate cell proliferation and differentiation associated with wound healing, angiogenesis, tissue regeneration, embryogenesis and CNS development.

Interactions
Alcohol and iodine may probably destroy the characteristic properties of aFGF which lead to the decrease of its activity. The skin on which Alcohol or iodine are used should be washed with normal saline prior to apply aFGF.

Use Level:
Repairing products : 10-15¼ g/ ml
Skin care / Serum / Cream : 1-5¼ g/ ml

Appearance : White lyophilized powder mass
Molecular weight : 15.5k Da
Purity ( HPLC and SDS-PAGE) : 95% min
Activity : Between 90% and 200% of 250000 IU/ mg
pH : 5.8-6.2
Preservative : Absent
Sterility Test : Sterile
Package : 0.1mg; 1.0mg and 10mg in ampoule or tiny bottle pack
Storage : Store the lyophilized product at -20° C, repeated freezing and thawing is not recommended.
Shelf life : 36 months on its original package at 2-8° C
Reconstitution : Reconstitute the product with a specially prepared solution, store at 2-8° C and prevent from microbial contamination.

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