Specification :

Mechanism
Yohimbine Hydrochloride is a selective competitive alpha2-adrenergic receptor antagonist. The alpha2 receptor is responsible for sensing adrenaline and noradrenaline and telling the body to decrease its production as part of a negative feedback loop.
Yohimbine also antagonizes several serotonin receptor subtypes: 1A (inhibitory, behavioral control), 1B (inhibitory, vasoconstriction),1D (inhibitory, vasoconstriction), and 2B (smooth muscle contraction). Since yohimbine is an antagonist, it will decrease the effects of these receptors, thus causing excitation, vasodilation, and smooth muscle relaxation.
Yohimbine is also said to increase dopamine and have some actions as an MAOI, although these mechanisms are unknown.
Production
Yohimbine is the principal alkaloid of the bark of the West-African evergreen Pausinystalia yohimbe Pierre (formerly Corynanthe yohimbe), family Rubiaceae (Madder family). There are 31 other yohimbane alkaloids found in Yohimbe. In Africa, yohimbine has traditionally been used as an aphrodisiac.However it is very important to note that while the terms yohimbine, yohimbine hydrochloride, and yohimbe bark extract are related, they are not interchangeable.
The active chemical present in yohimbe bark is Yohimbine HCl (indole alkaloid) found in the bark of the Pausinystalia yohimbe tree.
However, the levels of yohimbine that is present in yohimbe bark extract are variable and often very low. Therefore, although yohimbe bark has been used traditionally to reduce male erectile dysfunction, there is not enough scientific evidence to form a firm conclusion in this area.
Adverse effects
Yohimbine has significant side effects such as anxiety reactions. According to the Mayo Clinic, yohimbine can be dangerous if used in excessive amounts.
Higher doses of oral yohimbine may create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation.
It is thought to cause insomnia and sleeplessness in some users.
Product Line:
Pausinystalia yohimbe extract 4% Yohimbine
Pausinystalia yohimbe extract 8% Yohimbine
Pausinystalia yohimbe extract 50% Yohimbine
Pausinystalia yohimbe extract 99% YOHIMBINE HCL
Rauwolfia Serpentina (L) Benth Extract 99% ALPHA-(RAUWOLSCINE HCL) YOHIMBINE
HCLRauwolscine HCl 99%
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