Specification :

Chemical name:

Tilmicosin (IUPAC name): (10E, 12E)-(3R,4S,5S,6R,8R,14R,15R)-14-(6-deoxy-2,3-di-O-methyl-b-d-allo-hexopyran osyoxymethyl)-5-(3,6-dideoxy-3-dimethylamino-b-d-gluco-hexapyranosyloxy)-6-[ 2-(cis-3,5-dimethyl-piperidino)ethyl]-3-hydroxy-4,8,12-trimethyl-9-oxoheptad eca-10,12-dien-15-olide
Chemical Abstracts Services Name: tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-20-deoxy-20-(3,5- dimethyl-1-piperidinyl)-(20(cis: trans))

C.A.S. number: 108050-54-0

Synonyms: 20-Deoxy-20-(3,5-dimethylpiperidin-1-yl)-desmycosin

Structural formula

Molecular formula: C46H80N2O13

Molecular weight: 869.15

OTHER INFORMATION ON IDENTITY AND PROPERTIES

Pure active ingredient:

Melting point: Not determined

Solubility:

Freely soluble (1500 mg/L or greater) in organic solvents (hexane, acetone, acetonitrile, chloroform, dichloromethane, ethyl acetate, methanol, tetrahydrofuran); water solubility is temperature and pH dependent, but is 566 mg/mL at pH 7 and 25¡ãC.
Purity:

Tilmicosin consists of 82-88% cis isomer and 12-18% trans isomer, as determined by liquid chromatographic assay.