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Papaya ( Carica papaya) contains a substance called " papain" , which is chemically similar to " pepsin" , an enzyme that helps digest protein in the body. It is a safe and natural digestive aid. It' s easy enough to buy an over-the-counter alternative, but it is certainly not any better. In fact, in a lot of ways, it is much worse. If you take too many antacids, you run the risk of the " rebound effect, " that is, your body will respond by producing even more acid, which will cause even more gastrointestinal problems. Papaya juice or tablets, however, can be taken freely without any fear of rebounding. The fruit is also delicious and very popular in Hawaii.