AZD1152-hqpa

Quantity Order:

Payment Method:

Bank Cheque

M.Wt: 507.56
Formula: C26H30FN7O3
Solubility: DMSO
Purity: > 99%
Storage: at -20 2 years
CAS No.: 722544-51-6

AZD1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline Aurora kinase inhibitor [ AZD1152– hydroxyquinazoline pyrazol anilide ( HQPA) ] and is converted rapidly to the active AZD1152-HQPA in plasma . AZD1152-HQPA is a highly potent and selective inhibitor of Aurora B ( Ki, 0.36 nM) compared with Aurora A ( Ki, 1, 369 nM) and has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.

www.biochempartner.com

Recommend to your friends