Specification :

Azelnidipine(Calcium antagonist CAS:123524-52-7)
Molecular formula:C33H34N4O6
Molecular Weight :582.65
CAS:123524-52-7
Chemical Name:
(±)-3-(1-diphenylmethylazetidin-3-yl)5-isopropy12-amino-1,4-dihydro-6- methyl-4-(3-nitrophenyl)- 3,5-pyridinedicarboxylate
Application: hypertension
1: the pharmacological role of the Arab-Israeli horizon is a new type of folding dihydropyridine calcium channel blocker, calcium antagonist, it has generally do not have the characteristics, it can slow down the heart rate, and vascular tissue with a high affinity for its the role of moderate and rarely cause reflex tachycardia. Although the Arab-Israeli folding a single oral dose of nimodipine, its step-down response - time curve and the third generation calcium antagonist, amlodipine is very similar to, but after taking the Arab-Israeli horizon folding tachycardia caused by amlodipine than less. Long-term use in the Arab fold after nimodipine, compared with the control group, heart rate and PRA are on a downward trend.
Because of its high fat-soluble, are mainly distributed in the vascular tissue, so that in many animal models, nimodipine also showed that the Arab-Israeli folding a good anti-atherosclerosis and protection of the role of kidney and heart, therefore, the Arab-Israeli horizon discount can also be used for arterial the treatment of atherosclerosis.
2: Clinical evaluation of 1) anti-hypertension clinical report, the general calcium antagonist, is not applicable to the history of high blood pressure in patients with heart disease, because calcium antagonists as the rapid drop in blood pressure, reflex to stimulate the endocrine system, increasing heart rate. And the Arab-Israeli horizon is folded such restrictions do not apply. Blood pressure and heart rate because of the well and the Arab-Israeli horizon folding can be used to have a history of heart disease in patients with the treatment of hypertension.
Ah horizon in the treatment of high blood pressure discount arising, 24h row increased sodium and renal sodium excretion increased capacity of all to prove that it can promote urinary sodium excretion. Ah horizon discount treatment of high blood pressure is another feature of lipid metabolism or renal function does not have an adverse effect, orthostatic hypotension and sexual dysfunction and other side effects are also rare.
2) Nimodipine treatment of angina pectoris fold the Arab-Israeli attacks can be reduced angina frequency and nitroglycerin consumption, reducing myocardial ischemic angina attack frequency, so as to improve the patient's movement angina tolerance.